INDIVIDUAL TEST 008
C-/P-ANCA
Indication
Suspicion of systemic vasculitis and inflammatory diseases
Sample material
Serum
- Minim. volume: 0,5 mL
Transport
- Within Sweden: room temperature
- International: room temperature
Method
Indirect immunofluorescence (IIF)
Reference interval
<1:10 negative
Result
Results are reported as negative or positive with a titer.
Interpretation
C-ANCA is often caused by antibodies against proteinase-3 (PR3), a marker for the vasculitis disease granulomatosis with polyangiitis (GPA). In the first place, specific analyses of PR3-ANCA and MPO-ANCA are recommended if ANCA-associated vasculitis is suspected.
P-ANCA with specificity for myeloperoxidase (MPO) is a marker for the vasculitis microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA), but can also be found without associated vasculitis. Initially, specific analyses of PR3-ANCA and MPO-ANCA are recommended if ANCA-associated vasculitis is suspected.
P-ANCA with other specificity (for example, elastase or lactoferrin) can be seen in multiple different conditions, for example, inflammatory bowel disease, but has low clinical value.
MPO- and PR3-ANCA can occasionally give an atypical ANCA-pattern and determination of these specificities is recommended if ANCA-associated vasculitis is suspected. Atypical ANCA due to other antibody specificities has low clinical value.
References
- Suppiah R et al. Arthritis Rheumatol. 2022. 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Microscopic Polyangiitis. PMID: 35106973
- Grayson PC et al. Arthritis Rheumatol. 2022. 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis With Polyangiitis. PMID: 35106968
- Grayson PC et al. Arthritis Rheumatol. 2022. 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis With Polyangiitis. PMID: 35106968
- Rathmann J et al. Rheumatology (Oxford). 2024. Evaluation of the ACR/EULAR 2022 criteria for classification of ANCA-associated vasculitis in a population-based cohort from Sweden. PMID: 37758240
- Guchelaar NAD et al. Autoimmun Rev. 2021. The value of anti-neutrophil cytoplasmic antibodies (ANCA) testing for the diagnosis of ANCA-associated vasculitis, a systematic review and meta-analysis. PMID: 33197574
Last updated: 2025-10-09
Can't find what you're looking for? We are here to help
ENSKILD ANALYS 008
C-/P-ANCA
Indikation
Misstanke om systemisk vaskulit och inflammatoriska sjukdomar
Provmaterial
Serum
- Minim. volym: 0,5 mL
Transport
- Inom Sverige: rumstemperatur
- Internationellt: rumstemperatur
Metod
Indirekt immunofluorescens (IIF)
Referensintervall
<1:10 negativt
Resultat
Resultat anges som negativt eller positivt med titer.
Tolkning
C-ANCA är ofta uttryck för antikroppar mot proteinas-3 (PR3) som är markör för vaskulitsjukdomen granulomatos med polyangit (GPA). I första hand rekommenderas specifik analys av PR3-ANCA och MPO-ANCA vid misstanke om ANCA-associerad vaskulitsjukdom.
P-ANCA med specificitet för myeloperoxidas (MPO) är markör för vaskulitsjukdomarna mikroskopisk polyangit (MPA) och eosinofil granulomatos med polyangit (EGPA), men kan även ses utan koppling till vaskulit. I första hand rekommenderas specifik analys av PR3-ANCA och MPO-ANCA vid misstanke om ANCA-associerad vaskulitsjukdom.
P-ANCA med annan specificitet (t. ex elastas eller laktoferrin) kan ses vid en rad olika tillstånd bl.a. inflammatorisk tarmsjukdom, men har lågt diagnostiskt värde.
MPO- och PR3-ANCA kan i enstaka fall ge ett atypiskt ANCA-mönster och vidare analys av dessa specificiteter rekommenderas vid misstanke om ANCA-associerad vaskulitsjukdom. Atypisk ANCA som orsakas av andra antikroppsspecificiteter har lågt kliniskt värde.
Referenser
- Suppiah R et al. Arthritis Rheumatol. 2022. 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Microscopic Polyangiitis. PMID: 35106973
- Grayson PC et al. Arthritis Rheumatol. 2022. 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis With Polyangiitis. PMID: 35106968
- Grayson PC et al. Arthritis Rheumatol. 2022. 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology Classification Criteria for Eosinophilic Granulomatosis With Polyangiitis. PMID: 35106968
- Rathmann J et al. Rheumatology (Oxford). 2024. Evaluation of the ACR/EULAR 2022 criteria for classification of ANCA-associated vasculitis in a population-based cohort from Sweden. PMID: 37758240
- Guchelaar NAD et al. Autoimmun Rev. 2021. The value of anti-neutrophil cytoplasmic antibodies (ANCA) testing for the diagnosis of ANCA-associated vasculitis, a systematic review and meta-analysis. PMID: 33197574
Senast uppdaterat: 2025-10-09